OssDsign

The retrospective study carried out at Karolinska University Hospital in Sweden describes the clinical outcome of 50 patients who underwent cranioplasty with a total 53 OSSDSIGN® Cranial implants. 64% of the patients had experienced previous implant failures with other treatment options (autologous bone and/or alloplastic materials). 40 % of the patients had previous problems with infections, which is one of the most common complications leading to implant failure and subsequent explantation in cranioplasty.

In this patient cohort the explantation rate due to early post-operative infection for OSSDSIGN® Cranial was 1.9% (1/53) at a median follow-up time of 25 months. The explanted patient was successfully re-implanted with OSSDSIGN® Cranial without any signs of complications at the 6-month post-op follow-up. The publication concludes that OSSDSIGN® Cranial appears to have improved the clinical outcome, and particularly notes the regenerative effect of the implant as an important factor in achieving successful long-term outcome.

OssDsign® Cranial

OssDsign® Facial

OssDsign's bone regeneration technology provides improved healing properties that are clinically proven to enhance patient outcomes. By combining a regenerative calcium phosphate material with tailored patient-specific designs, the technology platform aims to contribute to the permanent healing of a range of bone defects.

UNIQUE IMPLANT PROPERTIES

OssDsign’s proprietary titanium-reinforced calcium phosphate implants are designed with the intention to eliminate the well-known lifelong risks posed by commonly used inert materials or autologous bone. Clinical experience shows lower rates of complications as compared to conventional techniques for craniofacial reconstruction.

CUSTOMIZED PATIENT-SPECIFIC DESIGNS

Every implant is tailored to the individual patient based on CAD technology and 3D printing. The result is a continuously expanding portfolio of custom-designed implants for a variety of clinical needs.

LONG-TERM HEALING, BONE INGROWTH AND REGENERATION

Histology, RT-PCR and PET-CT evidence has demonstrated the material’s ability not only to integrate with surrounding tissue structures, but to enable gradual bone ingrowth and new bone formation. For patients, benefits include less infections, sustained improvements in soft tissue quality and bone healing, with the aim of creating a permanent implant solution that eliminates the need for recurring surgical intervention.

OSSDSIGN® Facial is based on the succesful experience of OSSDSIGN® Cranial and provides surgeons with new opportunities to treat patients with complex facial skeletal defects. OSSDSIGN Facial is currently being introduced to selected facial reconstructive clinics throughout Europe.

THE CHALLENGE: ELIMINATE RESORPTION & INFECTION

Conventional materials used in facial reconstructive procedures have significant weaknesses. Patients receiving autologous bone transplants experience unpredictable resorption and reduction of bone volume whereas alloplastic implants, such as plastics and titanium, have risks of exposure and infection.

OUR SOLUTION: CUSTOMIZED REGENERATIVE IMPLANTS

Our proprietary calcium phosphate-based material composition, reinforced by titanium, and CAD-based manufacturing and design, OSSDSIGN® Facial provides new clinical opportunities for treatment of various facial bone deformities.
These include:

  • Repair of hereditary facial defects such as paranasal augmentation in cleft patients and correction of hemifacial microsomia.
  • Reconstruction of facial bone after trauma, tumor resection or growth retardation due to irradiation.